4-AcO-DMT (or psilacetin) is a semi-synthetic tryptamine closely related to the “magic mushroom” molecules psilocin and psilocybin. Like psilocybin, it appears to be metabolize by the body into psilocin.
Most people buy psilacetin as a brown or off-white powder, bosing.ut it’s also available in pills, tablets, capsules, and gel tabs among other preparations. Some trippers mix the powder with water just prior to d
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While some find the effects indistinguishable from psilocybin mushrooms, others say it’s more like DMT. The difference may be dose-dependent. But mystical-type experiences are common, as are philosophical insights and a sense of empathic well-being.
4-AcO-DMT, aka O-acetylpsilocin, is a novel tryptamine discover by Albert Hoffman in the 1950s. It is an O-acetate ester of psilocin.
While there are studies done on the use of serotonin 5-HT2A agonists in treating substance/drug use disorders, the neurological basis of these effects have yet to be elucidated. There is an interesting study done on the effects of 4-Aco-DMT on drug-dependent rats and mice, published in the European Journal of Neuroscience (EJN) (Vargas-Perez et al.).
Chronic use of drugs of abuse produce changes and cellular adaptations in neurons found in the VTA (Ventral Tegmental Area) of the brain, which is part of the dopamine reward pathway.
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These adaptations by BDNF (brain-derive neurotrophic factor).They are associats with the aversive withdrawal motivation. It leads to a drug-dependent state.
There is growing evidence that suggests that 5-HT2A receptor signaling can regulate the expression of BDNF in the brain. Both 5-HT and TrkB singaling are involved in modulating long term neuronal survival and plasticity but it is still unknown if these effects occur via a direct 5HT2A/TrkB interaction or downstream interactions between 5HT2A signalling/BDNF signalling.
In a study with 4-Aco-DMT, we observe that a single administration to the VTA of rats and mice blocks the aversive condition response to drug withdrawal as well as the mechanism that switches the drug-naive state to a drug-dependent system.
These studies indicated that 5-HT2A agonists can be used as therapeutic agents to reverse drug dependency and inhibit the aversive withdrawal response.
One article published by Vice Magazine referred to 4-AcO-DMT as “The Greatest Drug in the World” (Ticklish).
Our batch of 4-AcO-DMT has been used in scientific research as a standard for purity analysis, and has been confirmed as near 100% purity in a published paper from the University of Massachusetts (Chadeayne et al.).